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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages |
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| Authors: | Niamh C. Williams Dylan G. Ryan Ana S.H. Costa Evanna L. Mills Mark P. Jedrychowski Suzanne M. Cloonan Christian Frezza Luke A. O'Neill |
| Abstract: | |
| Keywords: | L-2-hydroxyglutarate, macrophage, inflammation, immunometabolism, hypoxia-inducible factor (HIF), interleukin 1β (IL-1β ), glycolysis |