| A hidden translatome in tumors——the coding lncRNAs |
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| 作者姓名： | Jinsong Wang Wenna Wang Fei Ma Haili Qian |
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| 作者单位： | 1. State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College;2. Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College |
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| 基金项目： | supported by the National Key Research and Development Program of China (2021YFF1201300, 2022YFE0103600)；;the National Natural Science Foundation of China (82073094)；;the Open Issue of State Key Laboratory of Molecular Oncology (SKL-KF-2021-16)；;the Independent Issue of State Key Laboratory of Molecular Oncology (SKL-2021-16)； |
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| 摘 要： | Long noncoding RNAs(lncRNAs) have been extensively identified in eukaryotic genomes and have been shown to play critical roles in the development of multiple cancers. Through the application and development of ribosome analysis and sequencing technologies, advanced studies have discovered the translation of lncRNAs. Although lncRNAs were originally defined as noncoding RNAs, many lncRNAs actually contain small open reading frames that are translated into peptides. This opens a broad area for the...
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