The preservation of nasal preparations |
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| Affiliation: | 1. School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, India;2. Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India;1. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus;2. Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany;1. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed University), M. B. Road, New Delhi 110062, India;2. Department of Pharmaceutics, School of Pharmacy, Glocal University, Saharanpur 247121, India;3. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia |
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| Abstract: | The intranasal route of administration provides an effective and convenient means of delivering a number of compounds to the systemic circulation when the more usual oral or parenteral routes are inappropriate. The preservation of multi-dose nasal drops and sprays is essential. However, preservatives should not impair any of the normal functions of the nasal cavity, such as mucociliary clearance, since patients with compromised clearance can suffer extensively from respiratory tract infections. This paper reviews the results of a number of investigations into the effects of a range of commonly used preservatives on the mucociliary clearance apparatus. |
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