Cyclo (His-Pro): a selective inhibitor of rat prolactin secretion in vitro期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Cyclo (His-Pro): a selective inhibitor of rat prolactin secretion in vitro

Authors:	C Prasad J F Wilber V Akerstrom A Banerji

Institution:	1. Section of Endocrinology, Department of Medicine, Louisiana State University Medical Center New Orleans, Louisiana 70112, USA;2. Department of Biochemistry, Louisiana State University Medical Center New Orleans, Louisiana 70112, USA

Abstract:	Cyclo (His-Pro) (10 ng/ml), inhibits KCl (59 mM) or thyrotropin-releasing hormone (10 ng/ml) stimulated, but not basal, release of prolactin from rat hemipituitaries $in vitro$ . However, cyclo (His-Pro) has no effect on the basal or stimulated release of thyrotropin and growth hormone. Cyclo (His-Pro) does not inhibit the binding of thyrotropin-releasing hormone to pituitary membrane suggesting that cyclo (His-Pro) inhibition of prolactin release is not mediated via the pituitary TRH-receptor.

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