Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats |
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Authors: | Sema Bolkent Refiye Yanardag Sehnaz Bolkent M Mutluhan Döger |
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Institution: | (1) Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, 34300-Cerrahpasa, Istanbul, Turkey;(2) Department of Chemistry, Faculty of Engineering, Istanbul University, 34850-Avcilar, Istanbul, Turkey;(3) Department of Biology, Faculty of Science, Istanbul University, 34459-Vezneciler, Istanbul, Turkey |
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Abstract: | Many studies have shown that niacin and Cr exert combined effects. Significant beneficial effects in serum lipid levels following
Cr supplementation have been reported. Niacin decreases total plasma levels of cholesterol, triglycerides, and low-density
lipoprotein cholesterol and increases high-density lipoprotein cholesterol. In this study, 12-mo-old female Swiss albino rats
were used. They were randomly divided into four groups. The animals of group I (control) were fed with pellet chow. Group
II was fed with pellet chow and treated with 250 μg/kg CrCl3·6H2O and 100 mg/kg niacin for 45 d, by the gavage technique. The rats of group III were fed with lipogenic diet consisting of
2% cholesterol 0.5% cholic acid, and 20% sunflower oil added to the pellet chow and given 3% alcoholic water for 60 d. Group
IV was fed with the same lipogenic diet, and 15 d after, the experimental animals were made hyperlipemic; they were treated
with 250 μg/kg CrCl3·6H2O and 100 mg/kg niacin by gavage technique for 45d. On d 60, liver and blood samples were taken from the animals. The sections
were examined under light and electron microscopes. Serum total lipid and cholesterol levels were determined by spectrophotometric
methods. The aim of the present study was *** DIRECT SUPPORT *** A02Q2015 00004 |
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Keywords: | Hyperlipemia liver niacin chromium morphology cholesterol total lipid |
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