Redox Biochemistry of Hydrogen Sulfide |
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Authors: | Omer Kabil Ruma Banerjee |
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Institution: | From the Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109 |
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Abstract: | H2S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of γ-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H2S production in the vasculature. However, patients with inherited deficiency in γ-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples it to oxidative phosphorylation while also exposing cytochrome c oxidase to this metabolic poison. This report focuses on the biochemistry of H2S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects. |
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Keywords: | Metabolism Metalloproteins Signal Transduction Sulfotransferase Sulfur Hydrogen Sulfide Sulfur Metabolism Transsulfuration |
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