Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane |
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| Authors: | G. A. Belitsky T. A. Lytcheva I. A. Khitrovo R. D. Safaev V. S. Zhurkov I. F. Vyskubenko L. P. Sytshova O. G. Salamatova E. G. Feldt V. V. Khudoley I. V. Mizgirev E. M. Khovanova E. G. Ugnivenko T. B. Tanirbergenov K. I. Malinovskaya Yu. A. Revazova F. I. Ingel V. A. Bratslavsky A. B. Terentyev A. A. Shapiro G. M. Williams |
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| Affiliation: | (1) Cancer Research Center AMS Russia, Moscow, Russia;(2) Institute of General and Communal Hygiene AMS Russia, Moscow, Russia;(3) Petrov Institute of Oncology, Russian Ministry of Health, Saint Petersburg, Russia;(4) Institute of Molecular Genetic AS Russia, Moscow, Russia;(5) Scientific Laboratory of Biological Active Substances of the Hydro Organisms, Russian Ministry of Health, Moscow, Russia;(6) Institute of Experimental Cardiology of the Cardiological Scientific Center AMS Russia, Moscow, Russia;(7) Institute of Preventive Toxicology, Russian Ministry of Health, Moscow, Russia;(8) Nesmeyanov Institute of Elementoorganic Compounds AS Russia, Moscow, Russia;(9) !["ldquo"]("/content/v013214718h11770/xlarge8220.gif") Ecotoc!["rdquo"]("/content/v013214718h11770/xlarge8221.gif") , Moscow, Russia;(10) American Health Foundation, Naylor Dana Institute for Disease Prevention, One Dana Road, 10595 Valhalla, New York, USA |
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| Abstract: | The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction inE. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) theSalmonella/microsome assay, (iv) a host-mediated assay usingSalmonella, (v) the somatic mutation and recombination assay inDrosophila melanogaster, (vi) HGPRT-mutagenesis assay in ARL 18 cells, and (vii) micronucleus formation assay in mouse polychromatophylic erythrocytes (PCE), forestomach (FS), glandular stomach (GS), duodenum (D), jejunum (J), cecum (C) and liver (L). The halopropanes were also tested for tumor formation in the fishDanio rerio. DBP was active in assays (ii), (v), (vii FS) and (vii L). TBP was positive in assays (ii) and (iii), strongly positive in (vii L) and borderline positive in (iv). However, neither DBP nor TBP induced tumors in fish, in contrast to the carcinogenic 1,2-dibromo-3-chloropropane. The genotoxicity and potential carcinogenicity of DBP and TBP in mammals is discussed.Abbreviations 2-AA 2-aminoanthracene - DBCP 1,2-dibromo-3-chloropropane - DBP 1,2-dibromopropane - HGPRT hypoxanthine-guanine phosphoribosyl transferase - i.p. intraperitoneal(ly) - NQO 4-nitro-quinoline-1-oxide - PCE polychromatic erythrocytes - TBP 1,1,3-tribromopropane - WME Williams' medium E |
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| Keywords: | carcinogenicity dibromopropane genetic toxicology mutagenicity tribromopropane |
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