Topical Niosome Gel of <Emphasis Type="Italic">Zingiber cassumunar</Emphasis> Roxb. Extract for Anti-inflammatory Activity Enhanced Skin Permeation and Stability of Compound D |
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Authors: | Aroonsri Priprem Khwanhatai Janpim Somsak Nualkaew Pramote Mahakunakorn |
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Institution: | 1.Division of Pharmaceutical Technology, Faculty of Pharmaceutical Science,Khon Kaen University,Khon Kaen,Thailand;2.Program in Pharmaceutical Chemistry and Natural Products, Faculty of Pharmaceutical Science,Khon Kaen University,Khon Kaen,Thailand;3.Division of Pharmacognosy and Medicinal Chemistry, Faculty of Pharmacy,Mahasarakham University,Mahasarakham,Thailand;4.Division of Toxicology, Faculty of Pharmaceutical Science,Khon Kaen University,Khon Kaen,Thailand |
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Abstract: | An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded thermal-accelerated decomposition of compound D in the gel (p?<?0.05) but did not change the activation energy of compound D. Niosomes enhanced in vitro permeation rate of compound D from the gel. Topical applications of ZC noisome gel gave a faster change in tail flick latency than piroxicam gel and hydrocortisone cream (p?<?0.05) while there were insignificant differences in anti-inflammatory activity up to 6 h using croton oil-induced ear edema model in mice (p?>?0.05). Thus, encapsulation of ZC extract in niosomes enhanced chemical stability and skin permeation with comparable topical anti-inflammatory effects to steroid and NSAID. |
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