Antibacterial and mutagenic activities of new isothiocyanate derivatives |
| |
Authors: | Sovcíková A Mikulásová M Horáková K Floch L |
| |
Institution: | (1) Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia;(2) Department of Organic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia |
| |
Abstract: | Nine newly synthetized isothiocyanate derivatives were demonstrated to posses antibacterial and genotoxic activitiesin vitro. 4-Hydroxybutyl isothiocyanate exhibited a broad antibacterial effect, with MIC values of 762 μmol/L forStaphylococcus aureus andEscherichia coli. Ethyl 4-methylsulfoxidobutanoate had the highest antibacterial activity in Gram-positive bacteria, the MIC value being 425
μmol/L forS. aureus. The highest tested concentrations of ethyl 4-isothiocyanatobutanoate and 4-hydroxybutyl isothiocyanate produced a bacteriocidal
effect in Gram-positive bacteria. The compounds showed no mutagenic effects onSalmonella typhimurium tester strains TA 98 and TA 100, either in the absence or in the presence of a metabolically active microsomal S9 fraction
from rat liver using standard Ames test. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|