Complement-dependent induction of DNA synthesis and cell proliferation in human liver connective tissue cells in vitro |
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Authors: | Alvaro N A Monteiro Radovan Borojevic |
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Institution: | (1) Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil |
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Abstract: | Summary Liver connective tissue cells (LCTC) isolated from patients with fibrotic livers have morphological and biochemical characteristics
of myofibroblasts. We have examined the proliferation of LCTC derived from normal livers and from livers with fibrosis of
different etiologies, as well as proliferation of skin fibroblasts. We have compared proliferation rates in the presence of
fresh human serum and heat-inactivated serum. While skin fibroblast and LCTC from normal liver showed no difference, proliferation
of LCTC from fibrotic livers was markedly decreased in the presence of heat-inactivated serum. We demonstrate that the native
complement component C1 is a factor involved in the induction of DNA synthesis and proliferation of LCTC isolated from fibrotic
livers. We propose that native C1, acting probably in cooperation with other growth factors, is involved in the expansion
of connective tissue cells during the development of liver fibrosis. |
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Keywords: | cell proliferation fibrosis liver connective tissue cells |
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