Effect of temperature on spinal cord regeneration in the weakly electric fish, Apteronotus leptorhynchus |
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Authors: | Ruxandra F Sîrbulescu Günther K H Zupanc |
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Institution: | (1) Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA;(2) School of Engineering and Science, Jacobs University Bremen, P.O. Box 750 561, 28725 Bremen, Germany; |
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Abstract: | Temperature manipulation has been shown to significantly affect recovery after spinal cord injury in various mammalian model
systems. Little has been known thus far about the impact of temperature on structural and functional recovery after central
nervous system lesions in regeneration-competent, poikilotherm organisms. In the present study, we addressed this aspect using
an established model of adult spinal cord regeneration, the weakly electric teleost fish Apteronotus
leptorhynchus. We observed an overall beneficial effect of increased temperature on both structural and behavioral recovery after amputation
of the caudal spinal cord. Fish kept at 30°C recovered the amplitude of the electric organ discharge at more than twice the
rate observed in fish kept at 22°C, within the first 20 days post-injury. This improved recovery was supported by increased
cell proliferation and decreased apoptosis levels in fish kept at 30°C. The high temperature appeared to have a direct inhibitory
effect on apoptosis and to lead to a compression of the duration of the wave of post-lesion apoptosis. The latter effect was
presumably induced through the acceleration of the metabolic rate, a phenomenon also supported by the observation that re-growth
of the tail was significantly increased in fish kept at 30°C. |
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