Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation |
| |
Authors: | Pengxia Niu Sang-Wook Kim Bong-Hwan Choi Tae-Hun Kim Jong-Joo Kim Kwan-Suk Kim |
| |
Affiliation: | 1. Department of Animal Science, Chungbuk National University, 410 Seongbong-ro, heungduk-gu, Cheongju-Si, Chungbuk, South Korea 2. Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Suwon, 441-706, Korea 3. School of Biotechnology, Yeungnam University, Gyeongsan, South Korea
|
| |
Abstract: | Previous studies have confirmed that insulin growth factor-1 (IGF1) plays important roles in growth and body size in humans and animals. However, whether single nucleotide polymorphisms (SNPs) within the IGF1 gene affects body size and growth in pigs has been unclear. We identified IGF1 SNPs among 5 pig breeds (Berkshire, Duroc, Landrace, Yorkshire and Korea Native Pig) and found that the G allele of SNP (c.G189A) was associated with higher body weight and was more predominant in western pig breeds, while the Korean Native Pig is the breed with the highest frequency of the A allele. Four haplotypes (–GA–, –GG–, –AG–, and –AA–) were constructed using the 2 identified SNPs. The GA haplotype was most frequently observed, except in the Berkshire breed. In addition, these SNPs and haplotypes were significantly associated with body size (final weight), average daily gain, and backfat thickness (P < 0.05) in 2 intercrossed F2 pig populations (KNP × YS F2 and KNP × LR F2). Furthermore, the major GA haplotype had a significant additive effect on body size and average daily gain. In conclusion, specific SNPs within the porcine IGF1 gene may contribute to the smaller body size and lower growth rate of Korea Native Pigs. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|