Post-duplication charge evolution of phosphoglucose isomerases in teleost fishes through weak selection on many amino acid sites |
| |
Authors: | Yukuto Sato Mutsumi Nishida |
| |
Institution: | (1) Division of Molecular Marine Biology, Ocean Research Institute, The University of Tokyo, 1-15-1 Minamidai, Nakano-ku, Tokyo 164-8639, Japan;(2) Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan |
| |
Abstract: | Background The partitioning of ancestral functions among duplicated genes by neutral evolution, or subfunctionalization, has been considered
the primary process for the evolution of novel proteins (neofunctionalization). Nonetheless, how a subfunctionalized protein
can evolve into a more adaptive protein is poorly understood, mainly due to the limitations of current analytical methods,
which can detect only strong selection for amino acid substitutions involved in adaptive molecular evolution. In this study,
we employed a comparative evolutionary approach to this question, focusing on differences in the structural properties of
a protein, specifically the electric charge, encoded by fish-specific duplicated phosphoglucose isomerase (Pgi) genes. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|