The determination of the local cerebral glucose utilization with the 2-deoxyglucose method |
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Authors: | A Wree A Schleicher |
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Institution: | (1) Anatomisches Institut der Universität Würzburg, Koellikerstrasse 6, D-8700 Würzburg, Germany;(2) Anatomisches Institut der Universität zu Köln, Joseph-Stelzmann Strasse 9, D-5000 Köln 41, Germany |
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Abstract: | Summary In the adult mammalian brain, the energy metabolism is almost entirely dependent on glucose. Furthermore, a close relationship between the energy metabolism and the functional activity could be shown. Thus, the functional activity of the brain or parts thereof can be quantified by measuring the cerebral metabolic rate for glucose. Studying in vivo the fate of a radioactive labeled analogue of glucose, the 2-deoxy-d-1-14C]glucose, and using quantitative autoradiographic techniques, it is possible to estimate the cerebral glucose utilization of every discrete brain region. The advantage of the 2-deoxyglucose method is, that the local cerebral glucose utilization represents a metabolic encephalography (Sokoloff 1982). |
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