Integrins: regulators of embryogenesis |
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Authors: | Darribère T Skalski M Cousin H L Gaultier A Montmory C Alfandari D |
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Affiliation: | Université P.-et-M.-Curie, U.M.R.-CNRS 7622, Laboratoire de Biologie Moléculaire et Cellulaire du Développement, Equipe Adhesion et Migration Cellulaires, Paris, France. |
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Abstract: | Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangements, co-regulation of growth factor activities and activation of signal transductions. This review describes experimental approaches that have given new insights into the integrin functions during embryogenesis. Using anti-functional antibodies, peptide inhibitors of integrin-ligand interactions and genetic ablation of integrins results, this review will show that integrins are key molecules during early development of both invertebrates and vertebrates. |
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Keywords: | integrins embryogenesis matrix adhesion development |
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