| 异丙肾上腺素对大鼠心内神经节中生长抑素(SS)影响的研究 |
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| 引用本文： | 范玉华,李玉明,殷树仪.异丙肾上腺素对大鼠心内神经节中生长抑素(SS)影响的研究[J].中国组织化学与细胞化学杂志,2000,9(4):463-466. |
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| 作者姓名： | 范玉华 李玉明 殷树仪 |
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| 作者单位： | 同济医科大学解剖学教研室!武汉430030(范玉华，殷树仪)，滨州医学院附属医院外科!山东256603(李玉明) |
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| 基金项目： | 卫生部科学研究基金资助课题!(No. 94- 1- 12 6 ) |
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| 摘 要： | 研究异丙肾上腺对心内神经节中肽能神经递质 SS的影响 ,本文在大鼠皮下注射异丙肾上腺素 5 m g/ kg,连续三天 ,固定后取心房后壁 ,用免疫组织化学结合图像分析方法观察大鼠心内神经节中肽能递质 SS的变化。对照组大鼠心内神经节中含有 SS免疫反应 (SS- IR)阳性神经纤维和细胞 ;实验组大鼠心内神经节中 SS- IR阳性神经纤维和神经元的积分光密度均明显减低。结果说明异丙肾上腺素可降低心内神经节中 SS含量 ,提示 ,异丙肾上腺素的正性变时和变力作用可能通过降低 SS的含量来实现。
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| 关 键 词： | 异丙肾上腺素 心内神经节 生长抑素 大鼠 |
THE
EFFECT OF ISOPROTERENOL ON CONTENT OF SOMATOSTATIN (SS)
IN RAT CARDIAC GANGLIA |
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| Fan Yuhua,Li Yuming,Yin Shuyi.THE
EFFECT OF ISOPROTERENOL ON CONTENT OF SOMATOSTATIN (SS)
IN RAT CARDIAC GANGLIA[J].Chinese Journal of Histochemistry and Cytochemistry,2000,9(4):463-466. |
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| Authors: | Fan Yuhua Li Yuming Yin Shuyi |
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| Abstract: | To study the effects of isoproterenol (ISP) on peptidergic transmitter SS in rat cardiac ganglia. Wistar rats were injected with ISP (5 mg/kg/day) for 3 days. The post wall of atria was removed after being fixed. The alteration of SS in rat cardiac ganglia was investigated by using immunohistochemical method and image analysis. SS immunoreactive positive (SS IR) neural fibers and neurons were found in control animal cardiac ganglia. In experimental group, the integrate optic density of SS IR neural fibers and neurons were decreased singnificantly. These findings suggest that ISP may decrease the content of SS in rat cardiac ganglia, and its positive inotropic and chronotropic effects on the heart can be achieved by decreasing the content of SS. |
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| Keywords: | Isoproterenol \ Cardiac ganglia \ Somatostatin Rat |
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