Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance |
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| Authors: | Turban Sophie Hajduch Eric |
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| Institution: | aCentre de Recherche des Cordeliers, INSERM, U872, Paris F-75006, France;bUniversité Pierre et Marie Curie, Paris VI, UMR S872, Paris F-75006, France;cUniversité Paris Descartes, UMR S872, Paris F-75006, France;dMolecular Metabolism Group, Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom |
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| Abstract: | The role of protein kinase C (PKCs) isoforms in the regulation of glucose metabolism by insulin is complex, partly due to the large PKC family consisting of three sub-groups: conventional, novel and atypical. Activation of some conventional and novel PKCs in response to increased levels of diacylglycerol (DAG) have been shown to counteract insulin signalling. However, roles of atypical PKCs (aPKCs) remain poorly understood. aPKCs act as molecular switches by promoting or suppressing signalling pathways, in response to insulin or ceramides respectively. Understanding how DAG- and ceramide-activated PKCs impair insulin signalling would help to develop treatments to fight insulin resistance. |
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| Keywords: | Insulin Ceramide DAG Protein kinase B Akt Obesity |
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