Increase in CIP2A expression is associated with doxorubicin resistance |
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| Authors: | Choi Yeon A Park Jeong Su Park Mi Young Oh Ki Sook Lee Myung Sok Lim Jong-Seok Kim Keun Il Kim Kun-yong Kwon Junhye Yoon Do Young Moon Eun-Yi Yang Young |
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| Institution: | aResearch Center for Women’s Disease, Department of Life Science, Sookmyung Women’s University, Seoul 140-742, Republic of Korea;bDepartment of Bioscience and Biotechnology, Bio/Molecular Informatics Center Konkuk University, Seoul 143-701, Republic of Korea;cDepartment of Bioscience and Biotechnology, Sejong University, 98 Kunja-dong Kwangjin-Gu, Seoul 143-747, Republic of Korea |
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| Abstract: | The cancerous inhibitor of protein phosphatase 2A (CIP2A) increases the migration and metastasis of various cancer cells. Overexpression of CIP2A has been shown to increase the proliferation of MDA-MB-231 cells. We thus assessed whether CIP2A expression is associated with sensitivity to doxorubicin. MDA-MB-231 cells showed an increase in CIP2A expression after treatment with doxorubicin, while MCF-7 cells showed a decrease in CIP2A expression. The overexpression of CIP2A in MCF-7 cells overcame the inhibition of cell proliferation in response to doxorubicin treatment. CIP2A expression was not affected by wild-type or mutant p53. However, mutant p53 blocked doxorubicin-mediated CIP2A down-regulation in HCT116 cells. As a regulation mechanism of doxorubicin-mediated CIP2A expression, we showed that phosphorylated Akt was involved in the suppression of CIP2A expression. |
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| Keywords: | Cancerous inhibitor of PP2A Doxorubicin Akt p53 |
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