The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines. |
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| Authors: | O K Haffar G R Nakamura and P W Berman |
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| Institution: | Department of Developmental Biology, Genetech Inc., South San Francisco, California 94080. |
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| Abstract: | Mutagenesis of the transmembrane domain and cytoplasmic tail of human immunodeficiency virus type 1 envelope glycoprotein gp160 revealed that its intracellular transport and processing in transfected cell lines were modulated by a functional domain included in the carboxy-terminal sequence consisting of residues 751 to 856. |
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