中国药用当归属植物研究进展及质量标志物的预测分析*

中国药用当归属植物资源丰富,包括当归、白芷、独活等34种药材,临床使用广且药用价值极高,富含香豆素类、多糖类、有机酸类、苯酚类、挥发油类等成分,除补血活血、调经止痛、润肠通便的传统功效,还具有抗氧化、抗衰老、保护神经元、抗肿瘤等药理作用,应用前景广阔。综述了中国药用当归属植物的分布及其药用功效、化学成分和药理作用的研究进展,为当归属植物的开发利用提供参考。并且根据质量标志物(Q-marker)概念,把影响中国药用当归属植物质量的因素概括为当归属药用植物品种、植物产区、化学成分、炮制方法,以及传统功效和网络药理学的预测分析等。从不同方面对中国药用当归属植物进行分析和论述,为建立和完善中国药用当归属植物的质量控制及评价方法提供参考。

Research Progress and Predictive Analysis of Quality Markers of Angelica Medicinal Plants in China

Chinese Angelica plants have rich plant resources, including 34 kinds of herbs such as Angelica, Angelica dahurica, and Angelicae Pubescentis Radix, widely used clinically and have high medicinal value. They are rich in coumarin, polysaccharide, organic acid, phenol, and naphtha. In addition to their traditional effects of replenishing the blood supply and invigorating the circulation of blood, regulating the menstrual cycle and relieving pain in the lower abdomen, and moistening intestines to relieve constipation, they also have anti-oxidation, anti-aging, neuron-protection, anti-tumor and other pharmacological effects. They have a broad application prospect. In this paper, the distribution, medicinal efficacy, chemical composition and pharmacological effect of Chinese Angelica plants were reviewed, which can provide reference for the development and utilization of Angelica plants. According to the concept of Q-marker, the factors affecting the quality of Chinese Angelica plants can be summarized as the varieties of medicinal plants, plant production areas, chemical components, processing methods, traditional efficacy and online pharmacology prediction and analysis. In order to provide reference for establishing and improving their quality control and evaluation methods, this paper analyzed and discussed the Chinese Angelica plants from different aspects.