Genome-wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats |
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| Authors: | Giulietta Minozzi Maria Grazia De Iorio Fiorentina Palazzo Gustavo Gandini Stefano Biffani Gianluigi Paolillo Elena Ciani Vincenzo Di Marco Lo Presti Alessandra Stella John L Williams |
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| Institution: | 1. Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, Lodi, Italy;2. Faculty of Bioscience and Technology for Food, Agriculture and Environment, Università degli Studi di Teramo, Teramo, Italy;3. Institute of Agricultural Biology and Biotechnology, National Research Council, Milano, Milano, Italia;4. Department of Biosciences, Biotechnologies and Biopharmaceutics, Università degli Studi di Bari ‘Aldo Moro’, Bari, Italy;5. Istituto Zooprofilattico Sperimentale della Sicilia ‘A. Mirri’, Area Territoriale Barcellona Pozzo di Gotto, Messina, Italy;6. School of Animal and Veterinary Sciences, Davies Research Centre, University of Adelaide, Adelaide, South Australia, Australia |
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| Abstract: | Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case–control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 × 10−5). These results provide evidence for genetic loci involved in the antibody response to MAP in goats. |
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| Keywords: | caprine ELISA genetic association paratuberculosis SNPs |
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