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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus |
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| Authors: | Xing-Lou Yang Ben Hu Bo Wang Mei-Niang Wang Qian Zhang Wei Zhang Li-Jun Wu Xing-Yi Ge Yun-Zhi Zhang Peter Daszak Lin-Fa Wang Zheng-Li Shi |
| Affiliation: | aKey Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China;bYunnan Institute of Endemic Diseases Control and Prevention, Dali, China;cEcoHealth Alliance, New York, New York, USA;dProgram in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore |
| Abstract: | We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans. |
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