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Characterization of the tissue-specific expression of the S100P gene which encodes an EF-hand Ca2+-binding protein* |
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| Authors: | Jin Gang Wang Shu Hu Xiangui Jing Zaiping Chen Jinzhong Ying Kang Xie Yi Mao Yumin |
| Institution: | (1) Department of General Surgery, Changhai Hospital, Shanghai, 200433, People's Republic of China;(2) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China;(3) Present address: Department of Genetics, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA |
| Abstract: | S100 proteins are a calcium-binding protein family containing two EF-hand domains exclusively expressed in vertebrates and play roles in many cellular activities. Human S100P gene was first cloned as a 439 bp cDNA in placenta and it was found to be associated with human prostate cancer. Here we describe the cloning of the 1297 bp full-length cDNA, and the characterization of the tissue-specific expression of the human S100P gene. It is abundantly expressed in many tissues including placenta by Northern blot and RT-PCR analysis, unlike the expression pattern of other S100 family genes. |
| Keywords: | S100 proteins calcium-binding protein signal transduction EF-hand RT-PCR |
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