Existence of carcinine, a histamine-related compound, in mammalian tissues |
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Authors: | L Flancbaum D N Brotman J C Fitzpatrick T Van Es E Kasziba H Fisher |
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Affiliation: | Dept. of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey. |
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Abstract: | Carcinine (beta-alanylhistamine) was synthesized in vitro from histamine and beta-alanine. It was detected quantitatively using an HPLC method previously described for the quantification of the related compounds histamine, histidine, carnosine and 3-methylhistamine. Carcinine was identified in several tissue of the rat, guinea pig, mouse and human, and was then shown to be metabolically related in vivo to histamine, histidine, carnosine and 3-methylhistamine through radioisotopic labeling. The results demonstrate that carcinine may be concurrently quantitated using the same HPLC method as that used to measure histamine, histidine, carnosine and 3-methylhistamine. These findings suggest a role for carcinine in the carnosine-histidine-histamine metabolic pathway and in the mammalian physiologic response to stress. |
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