Prediction of protein binding sites in protein structures using hidden Markov support vector machine |
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| Authors: | Bin Liu Xiaolong Wang Lei Lin Buzhou Tang Qiwen Dong and Xuan Wang |
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| Institution: | (1) Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, PR China;(2) School of Computer Science and Technology, Harbin Institute of Technology, Harbin, PR China;(3) Department of Control Science and Engineering, Harbin Institute of Technology, Harbin, PR China;(4) School of Computer Science, Fudan University, Shanghai, PR China |
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| Abstract: | Background Predicting the binding sites between two interacting proteins provides important clues to the function of a protein. Recent
research on protein binding site prediction has been mainly based on widely known machine learning techniques, such as artificial
neural networks, support vector machines, conditional random field, etc. However, the prediction performance is still too
low to be used in practice. It is necessary to explore new algorithms, theories and features to further improve the performance. |
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