<Emphasis Type="SmallCaps">l</Emphasis>-Proline is a sedative regulator of acute stress in the brain of neonatal chicks |
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| Authors: | K Hamasu T Haraguchi Y Kabuki N Adachi S Tomonaga H Sato D M Denbow M Furuse |
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| Institution: | (1) Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan;(2) Ajinomoto Co., Inc, Kawasaki-ku, Kawasaki 210-8681, Japan;(3) Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0306, USA; |
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| Abstract: | The purpose of the present study was to clarify the central nervous system function of amino acids during acute stress. In
Experiment 1, changes in free amino acid pattern were investigated in the brain of neonatal chicks exposed to either restraint
with isolation-induced or fasting stress. l-Proline and l-arginine were decreased in the telencephalon and diencephalon under any stress. Since the central nervous system functions
of l-arginine during the stress response has recently been reported, in Experiment 2, the effect of intracerebroventricular injection
of l-proline (0.5, 1.0, 2.0 μmol) during isolation-induced stress was investigated. l-Proline induced sedative and hypnotic effects in a dose-dependent manner. It is suggested that l-proline may have an important role to attenuate the stress response in the central nervous system of chicks. |
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