Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients |
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| Authors: | Ay?e Yüzba?io?lu Hülya Karata? Yasemin Gürsoy-Özdemir Serap Saygi Nejat Akalan Figen Söylemezo?lu Turgay Dalkara Y Çetin Kocaefe Meral Özgüç |
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| Institution: | (1) Department of Medical Biology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey;(2) Institute of Neurological Sciences and Psychiatry, Department of Neurology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey;(3) Department of Neurology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey;(4) Department of Neurosurgery, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey;(5) Department of Pathology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey; |
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| Abstract: | Selenoproteins are enzymes containing selenium in their structure and are involved in cellular processes such as defense against
oxidative stress and cell survival. The aim of this study is to investigate the expression of four selenoproteins (GPX1, TRXR1,
SELP and SELW) in the hippocampus of intractable mesial temporal lobe epilepsy (MTLE) patients who underwent curative surgery.
The selenoproteins is investigated at the mRNA level via RT-PCR and in situ hybridization and by immunostaining at the protein
level. The expression of SELW exhibited a relative induction of more than tenfold, and immunostaining findings provided evidence
that this upregulation is confined to neurons. GPX1 was also upregulated 2.3-fold, and TRXR1 was downregulated between 70
and 20% in MTLE patients. The profound induction of SELW has been accompanied by GPX1 and displayed a strong correlation with
BCL2 expression, suggesting a protective role for these selenoproteins, and may be an indicator of a defense mechanism in
surviving neurons. |
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