The applicability of an amidated polysaccharide hydrogel as a cartilage substitute: structural and rheological characterization |
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Authors: | Leone Gemma Delfini Maurizio Di Cocco Maria Enrica Borioni Anna Barbucci Rolando |
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Institution: | CRISMA and Department of Chemical and Biosystem Science and Technologies, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. |
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Abstract: | An amidic derivative of a carboxymethylcellulose-based hydrogel was obtained and characterized in terms of amidation degree. NMR studies and FT-IR imaging spectroscopy demonstrated that the reaction allowed a polymer to be obtained that was characterized by a regular distribution of amidic groups along the polysaccharide chains. Through this regularity, a homogenous three-dimensional scaffold was obtained, which maintained the thixotropic property of the linear polysaccharide. |
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Keywords: | Amidic carboxymethylcellulose Hydrogel NMR FT-IR Imaging |
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