Antigen-specific augmentation of murine immediate hypersensitivity-like footpad reaction by a T-cell factor in the culture supernatant of immune spleen cells |
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| Authors: | A Yamada K Himeno Y Kumazawa K Nomoto |
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| Affiliation: | 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Wihuri Research Institute, Helsinki, Finland;3. Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy;4. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;7. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | An antigen-specific factor capable of augmenting delayed-type hypersensitivity (DH) in the culture supernatants from immune spleen cells and erythrocyte antigen has been found. These culture supernatants also augmented an immediate hypersensitivity-like reaction which appeared in advance of the classical DH reaction. In this paper, the basic characteristics and cells producing the augmentation factor (IAF) involved in immediate hypersensitivity-like reaction were investigated. Maximum activity of IAF was detected in a supernatant from 24-hr culture of immune spleen cells and antigen. In vitro antigen stimulation was essentially required for the production or release of IAF. IAF showed antigen-specificity. IAF was produced or released by T cells. In addition to these facts, the DH-augmentation factor proved to be a T-cell product. |
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