The binding of 3H-Isoguvacine to mouse brain synaptic membranes |
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| Authors: | Anne M Morin Claude G Wasterlain |
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| Institution: | Neurology and Epilepsy Research Laboratories Veterans Administration Medical Center Sepulveda, California and Department of Neurology and Brain Research Institute, School of Medicine, University of California, Los Angeles, California, USA |
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| Abstract: | 3H-Isoguvacine, a gamma aminobutyric acid (GABA) agonist, has been shown to bind to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus. It is suggested that isoguvacine binds to GABA binding sites and therefore represents a new ligand for measuring GABA receptor binding. |
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