Parallel inhibition of neutrophil arachidonic acid metabolism and lysosomal enzyme secretion by nordihydroguaiaretic acid |
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| Authors: | R.W. Walenga H.J. Showell M.B. Feinstein E.L. Becker |
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| Affiliation: | Departments of Pharmacology and Pathology University of Connecticut Health Center Farmington, Connecticut 06032, USA |
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| Abstract: | Arachidonic acid at concentrations from 0.2 to 2.0 × 10?6M induces the secretion of lysosomal enzymes from cytochalasin B-treated rabbit neutrophils. These concentrations of arachidonic acid are metabolized primarily to hydroxyeicosatetraenic acids rather than to cyclooxygenase products. A good correlation is observed between the extent of arachidonic acid metabolism and the secretion of lysosomal enzymes. Nordihydroguaiaretic acid (1?10μM) inhibits both lysosomal enzyme secretion and the production of lipoxygenase products by neutrophils. |
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