Procoagulant effect of phenobarbital in rats |
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Authors: | Avraham Yacobi John T. Slattery Gerhard Levy |
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Affiliation: | Department of Pharmaceutics School of Pharmacy State University of New York at Buffalo Amherst, N.Y. 14260 USA |
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Abstract: | Daily administration of phenobarbital, 75 mg/kg ip for 4 days, to adult male Sprague-Dawley rats produced a pronounced increase of prothrombin complex activity (PCA) in plasma, i.e. a decrease of the prothrombin time. This effect persisted for 4 to 5 days after the last dose of phenobarbital. The rate constant for the decline of PCA after administration of a PCA synthesis-blocking dose of warfarin was not affected by treatment with phenobarbital but the rate of synthesis of PCA was increased appreciably. Thus, the phenobarbital-induced increase of PCA was caused by increased synthesis of one or more clotting factors. |
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Keywords: | To whom reprint requests should be addressed. |
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