The possible significance of intracellular pH in insulin release

Glucose and other nutrients which stimulate insulin release increase the rate of H⁺ generation and inhibit Na⁺Ca²⁺ counter-transport in the pancreatic B-cell. It is proposed that the latter phenomena are linked together by interference with an ionophoretic system. Indeed, in an artificial model, it is possible to mimick the process of Ca²⁺ countertransport and its inhibition in response to intracellular acidosis, by using native ionophores extracted from isolated pancreatic islets.