Increase in glutamate receptors following repetitive electrical stimulation in hippocampal slices |
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Authors: | M. Baudry M. Oliver R. Creager A. Wieraszko G. Lynch |
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Affiliation: | 1. Department of Psychobiology University of California Irvine, California 92717, USA;1. Department of Biochemistry of Nervous System and Muscle Nencki Institute of Experimental Biology Warsaw, Poland |
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Abstract: | Repetitive electrical stimulation of identified pathways in the hippocampal slice preparation induces long-term potentiation (LTP) of synaptic transmission and is accompanied by a long-lasting (up to 30 minutes) increase in L-3H-glutamate accumulation by the slices. This increased accumulation of 3H-glutamate is restricted to the terminal field of the stimulated fibers and does not seem to represent a non-specific increased accumulation of amino acids. In addition, synaptic membranes prepared from stimulated slices exhibit an increase in the maximal number of the sodium-independent high-affinity binding sites for 3H-glutamate without changes in their affinity. These results suggest that repetitive electrical stimulation elicits an increased number of glutamate receptors which might be responsible for LTP. |
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