N-hydroxymethylpentamethylmelamine,a major metabolite of hexamethylmelamine |
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Authors: | Andreas Gescher,Maurizio D Incalci,Roberto Fanelli,Pierluigi Farina |
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Affiliation: | 1. Cancer Chemotherapy Research Group, Department of Pharmacy University of Aston, Gosta Green, Birmingham, B4 YET, U.K.;2. Mario Negri Institute for Pharmacological Research Via Eritrea, 62 - 20157 Milan, Italy |
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Abstract: | N-Hydroxymethylpentamethylmelamine (HMPMM) was identified by HPLC and by GLC-MS after derivatization, as a metabolite of the anticancer drug hexamethylmelamine (HMM) in incubation mixtures with fortified mouse liver 9000 × g and microsomal preparations. HMPMM formation was dependent on the presence of NADPH and oxygen. N-demethylated metabolites were also found. HMPMM displays appreciable chemical stability and 29% was recovered after 60 min incubation in buffer. HMPMM constituted more than 50% of total HMM metabolites in 30 min incubations. The known chemical reactivity of carbinolamines means that HMPMM could be involved in the pharmacological or toxic effects of HMM. |
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Keywords: | Address correspondence to: M. D'INCALCI M.D. |
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