Role of angiotensin II in oral contraceptive hypertension in anesthetized rats |
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Authors: | David H Stubbs J Alan Johnson Shuichi Ichikawa Wayne L Fowler Jeannette Kilfoil W Ford Keitzer |
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Institution: | Harry S Truman Memorial V. A. Hospital, and Departments of Physiology and Surgery, University of Missouri, Columbia, Missouri 65201, USA |
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Abstract: | Rats fed a diet containing an oral contraceptive estrogen-progestogen mixture (Enovid) for 26 weeks developed a significant (P<0.01) elevation in mean arterial pressure (145 ± 6 mm Hg) when compared to a control group of rats fed the same diet without oral contraceptive steroids (mean arterial pressure averaged 117 ± 6 mm Hg). Infusion of Sar1, Ala8] angiotensin II, a competitive antagonist of angiotensin II, reduced the mean arterial pressure (P<0.01) in the oral contraceptive-treated rats to 117 ± 9 mm Hg, while infusion of this angiotensin II analogue into the control rats did not lower the arterial pressure. These studies provided evidence that angiotensin II may be involved in the hypertension produced by Enovid treatment in rats. |
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Keywords: | Address reprint requests to: J Alan Johnson Ph D Research Service (151) Harry S Truman Mem V A Hospital Columbia Mo 65201 |
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