Comparative Studies on Functions of Human Adenovirus Type 12 and Its Low Oncogenic Mutant Virions |
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Authors: | Hisanori Ezoe and Stanley Mak |
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Institution: | Department of Biology, McMaster University, Hamilton, Ontario, Canada |
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Abstract: | Physical and biological properties of highly oncogenic human adenovirus type 12 were compared with a low oncogenic mutant (cyt mutant). Parental and cyt mutant virions had very similar density and DNA size. However, the parental strain virion preparations contained a much higher proportion of defective virions (capable of cell killing, but not able to induce T- or V-antigen) than cyt mutant stock. It was also found that cyt mutant had a reduced virus yield in several human cell lines compared with the parental strain. |
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