Involvement of peripheral noradrenaline and 5-hydroxytryptamine in carrageenin-induced pedal oedema in rats |
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Authors: | P P Singh A Y Junnarkar D R Shridhar |
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Institution: | (1) Department of Pharmacology, IDPL Research Centre, 500 037 Hyderabad, India |
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Abstract: | Role of peripheral and central noradrenaline and 5-hydroxytryptamine in the carrageenin-induced pedal oedema in rats was studied
using agents which influence catecholamine synthesis and receptor activity of noradrenaline and 5-hydroxytryptamine. Reserpine,
guanethidine, α-methyl-p-tyrosine, diethyldithiocarbamate, 6-hydroxydopamine, phenoxybenzamine, phentolamine, chlorpromazine and yohimbine markedly
inhibited carrageenin-induced pedal oedema. However, 6-hydroxydopamine given intracerebroventricularly, 5,6-dihydroxytryptamine,p-chlorophenylalanine, lower dose of yohimbine, pro pranolol, haloperidol, cyproheptadine and mepyramine did not alter the
carrageenin-induced oedema, whereas, cyproheptadine and mepyramine given simultaneously, markedly inhibited carrageenin-induced
oedema. Our studies indicate that the process of oedema formation in rats by carrageenin involves both the peripheral noradrenaline
and 5-hydroxytryptamine
Communication No. 58 from IDPL Research Centre, Hyderabad. |
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Keywords: | Carrageenin-induced oedema noradrenaline-5-hydroxytryptamine-mediators |
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