| Abstract: | Response to application of and superfusion with solutions containing arginine-vasopressin and its derivatives (VPS), was investigated in identifiedHelix pomatia neurons. Different VPS exerted a similar effect on neurons in all cases. De- and hyperpolarizing as well as modulatory effects were shown. Depolarizing and hyperpolarizing response was accompanied by a rise and fall in steady-state conductance of the cell membrane. Reversal potential of response was determined as in the region of chloride reversal potential. Adding furosemide to the extracellular solution reversibly inhibited response to VPS. It was concluded from this that both de- and hyperpolarizing response took the form of an increase in the amplitude of trans-membrane ionic current induced by injecting cAMP into the neuron under the effects of superfusing the preparation with a VPS-containing VPS solution. Specific VPS receptors, probably associated with the cell cyclic nucleotide system, are thought to exist at the membrane of someHelix pomatia neurons.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 22, No. 3, pp. 368–373, May–June, 1990. |
