Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from alpha-amino acids |
| |
| Authors: | Groarke M Hartzoulakis B McKervey M A Walker B Williams C H |
| |
| Affiliation: | School of Chemistry, The Queen's University, Belfast, UK. |
| |
| Abstract: | The reductive amination of an amino acid derived glyoxal, with the free amino group of a protected amino acid or oligopeptide fragment, has been developed as a simple and efficient method for the preparation of ketomethylene amino pseudo-oligopeptide isosteres Aa psi(COCH2NH)Aa. Trichlorosilane-DMF is the reagent of choice for the reduction. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
