Sequence and expression analysis of the gene encoding inducible cAMP early repressor in tilapia |
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Authors: | Ming Chen Rui Wang Xi Gan Aiying Lei Chao Li Xiaoli Yu Jun Huang Ting Huang Wanwen Liang |
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Institution: | (1) Guangxi Institute of Fisheries, 530021 Nanning, Guangxi, People’s Republic of China;(2) College of Animal Science and Technology, Guangxi University, 530005 Nanning, Guangxi, People’s Republic of China; |
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Abstract: | Suppression subtractive hybridization library was generated by comparison of cDNA populations isolated from peripheral leukocytes
of pre- and post-immunized tilapia. One cDNA sequence encoding complete inducible cAMP early repressor was obtained from the
library. The sequence was characterized by the presence of the basic structure of ICER IIγ. Expression of ICER was in the
tissues of four types of tilapia was decreased after infection with Streptococcus. After immunization, expression of ICER was initially decreased and then increased after 7 days. In addition, the order for
the overall expression of ICER gene after infection and the increases of ICER expression later after immunization in these
four types of tilapia was positively correlated to the disease resistance and productivity of these four species of tilapia.
Our results provided molecular mechanisms for the different disease resistance capability in different species of tilapia.
In addition, our results also provided reference molecular marker for breeding disease resistant tilapia, cAMP responsive
element modulator. |
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Keywords: | |
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