MicroRNAs take part in pathophysiology and pathogenesis of Male Pattern Baldness |
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Authors: | Hamed R Goodarzi Ali Abbasi Mojtaba Saffari Mohammad B Tabei Mohammad R Noori Daloii |
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Institution: | (1) Department of Medical Genetics, Medical School, Tehran University of Medical Sciences, Poorsina Street, Tehran, Iran;(2) Hair Transplant Surgery Unit, Abbasi Hair Clinic, Vanak Square, Tehran, Iran;(3) Department of Medical Genetics, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; |
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Abstract: | Male Pattern Baldness (MPB) or androgenetic alopecia is a common form of hair loss with androgens and genetics having etiological
significance. Androgens are thought to pathophysiologically power on cascades of chronically dramatic alterations in genetically
susceptible scalp dermal papillas, specialized cells in hair follicles in which androgens react, and finally resulting in
a patterned alopecia. However, the exact mechanisms through which androgens, positive regulators of growth and anabolism in
most body sites, paradoxically exert their effects on balding hair follicles, are not yet known. The role of microRNAs, a
recently discovered class of non-coding RNAs, with a wide range of regulatory functions, has been documented in hair follicle
formation and their deregulation in cancer of prostate, a target organ of androgens has also been delineated. Yet, there is a lack of knowledge in agreement with microRNAs’ contribution in pathophysiology of MPB. To investigate the
role of microRNAs in pathogenesis of MPB, we selected seven microRNAs, predicted bioinformatically on a reverse engineering
basis, from previously published microarray gene expression data and analyzed their expression in balding relative to non-balding
dermal papillas. We found for the first time upregulation of four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that
could participate in pathogenesis of MPB. Regarding microRNAs’ therapeutic potential and accessibility of hair follicles for
gene therapy, these microRNAs can be considered as good candidates for a new revolutionized generation of treatments. |
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