HAEMOPOIETIC STEM CELL (CFU) KINETICS IN THE CULTURE |
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| Authors: | J L Chertkov Nina L Samoylina Nina A Rudneva A M Rakcheev Nona F Kondratenko |
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| Institution: | Laboratory for Culture and Transplantation of Bone Marrow, The Central Institute of Hematology and Blood Transfusion, Moscow, U.S.S.R. |
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| Abstract: | Haemopoiesis continued for over 2 months in organ culture of embryonal mouse liver, and haemopoietic stem cells (CFUs) capable of DNA-synthesis were found in it all that time. Between the 10th and 40th day the number of stem cells in the culture was sustained in a steady state. Both in normal and in regenerating adult bone marrow haemopoiesis ceased within a short time in the culture. Induction of proliferation in haemopoietic stem cells combined with undamaged or improved micro-environment resulted in a little better maintenance of CFUs in the adult bone marrow culture, The results are discussed in the light of current concepts of haemopoietic stem cell regulation. |
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