Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation |
| |
Authors: | Cossarizza Andrea Pinti Marcello Nasi Milena Gibellini Lara Manzini Serena Roat Erika De Biasi Sara Bertoncelli Linda Montagna Jonas P Bisi Luca Manzini Lisa Trenti Tommaso Borghi Vanni Mussini Cristina |
| |
Institution: | aDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, via Campi 287, 41125 Modena, Italy;bInfectious Diseases Clinics, Azienda Ospedaliero-Universitaria Policlinico di Modena, via del Pozzo 71, 41124 Modena, Italy;cDepartment of Clinical Pathology, NOCSAE - Baggiovara Hospital, Modena, Italy |
| |
Abstract: | HIV infection is characterized by a chronic inflammatory state. Recently, it has been shown that mitochondrial DNA (mtDNA) released from damaged or dead cells can bind Toll like receptor-9 (TLR9), an intracellular receptor that responds to bacterial or viral DNA molecules. The activation of TLR9 present within monocytes or neutrophils results in a potent inflammatory reaction, with the production of proinflammatory cytokines. We measured plasma levels of mtDNA in different groups of HIV+ patients, i.e., those experiencing an acute HIV infection (AHI), long term non progressors (LTNP), late presenters (LP) taking antiretroviral therapy for the first time, and healthy controls. We found that in AHI and LP mtDNA plasma levels were significantly higher than in healthy individuals or in LTNP. Plasma mtDNA levels were not correlated to peripheral blood CD4+ T cell count, nor to markers of immune activation, but had a significant correlation with plasma viral load, revealing a possible role for mtDNA in inflammation, or as a biomarker of virus-induced damage. |
| |
Keywords: | mtDNA HIV AIDS LTNP Mitochondrial damage-associated molecular patterns Inflammation TLR-9 |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|