Hydra: software for tailored processing of H/D exchange data from MS or tandem MS analyses |
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Authors: | Gordon W Slysz Charles AH Baker Benjamin M Bozsa Anthony Dang Andrew J Percy Melissa Bennett David C Schriemer |
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Affiliation: | (1) Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada |
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Abstract: | Background Hydrogen/deuterium exchange mass spectrometry (H/DX-MS) experiments implemented to characterize protein interaction and protein folding generate large quantities of data. Organizing, processing and visualizing data requires an automated solution, particularly when accommodating new tandem mass spectrometry modes for H/DX measurement. We sought to develop software that offers flexibility in defining workflows so as to support exploratory treatments of H/DX-MS data, with a particular focus on the analysis of very large protein systems and the mining of tandem mass spectrometry data. |
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