The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis |
| |
| Authors: | Timms Andrew E Crane Alison M Sims Anne-Marie Cordell Heather J Bradbury Linda A Abbott Aaron Coyne Mark R E Beynon Owen Herzberg Ibi Duff Gordon W Calin Andrei Cardon Lon R Wordsworth B Paul Brown Matthew A |
| |
| Institution: | Institute of Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford, United Kingdom. |
| |
| Abstract: | Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
