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Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series |
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| Authors: | Watterson Scott H Carlsen Marianne Dhar T G Murali Shen Zhongqi Pitts William J Guo Junqing Gu Henry H Norris Derek Chorba John Chen Ping Cheney Daniel Witmer Mark Fleener Catherine A Rouleau Katherine Townsend Robert Hollenbaugh Diane L Iwanowicz Edwin J |
| Institution: | Bristol-Myers Squibb PRI, PO Box 400, Princeton, NJ 08543-4000, USA. scott.waterson@bms.com |
| Abstract: | A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described. |
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