Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin |
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| Authors: | Qiu Wen-Wei Xu Jie Liu Da-Zhi Li Jing-Ya Ye Yang Zhu Xing-Zu Li Jia Nan Fa-Jun |
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| Institution: | Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, 189 Guo-Shou-Jing Road, Shanghai 201203, China. |
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| Abstract: | A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins. |
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