Macromolecular synthesis in mitochondria isolated from different regions of developing rat brain |
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Authors: | Maria N Gadaleta Anna M Giuffrida Marcella Renis Ida Serra Giovanna Del Prete Ernesto Geremia Cecilia Saccone |
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Institution: | (1) Institutes of Biological Chemistry, Universities of Bari, Italy;(2) Institutes of Biological Chemistry, Universities of Catania, Italy;(3) Mental Hospital of Bisceglie, Italy |
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Abstract: | DNA, RNA, and protein synthesis in mitochondria isolated from cerebral hemispheres, brain stem, and cerebellum of 10- and 30-day-old rats was measured. Synthesis of different macromolecules was affected by the respective mitochondrial specific inhibitors, showing a good level of purity of mitochondrial preparations. DNA and protein synthesis in 10-day-old rats was about 70% higher than in 30-day-old animals. In contrast, RNA synthesis did not decrease with age in all the regions examined. |
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