Iron accumulation in tissues of magnesium-deficient rats with dietary iron overload |
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Authors: | Mieko Kimura Katsuhiko Yokoi |
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Institution: | (1) Department of Social Medicine, Graduate School of Medicine, Kyoto University, Konoecho Yoshida Sakyoku, 606-01 Kyoto, Japan |
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Abstract: | The mineral imbalances in magnesium-deficient rats with dietary iron overload were studied. Forty-four male Wister rats were
divided into six groups and fed six diets, two by three, fully crossed: magnesium adequate or deficient, and iron deficient,
adequate, or excess. The concentrations of iron, magnesium, calcium, and phosphorus in tissues of the rats were measured.
The results were as follows: (1) The excess iron intake reinforced the iron accumulation in liver and spleen of magnesium
deficient rats; (2) The saturation of iron binding capacity was enormously elevated in the magnesium deficient rats fed excess
iron; and (3) Dietary iron deprivation diminished the degree of calcium deposition in kidney of magnesium deficient rats.
These results suggest that magnesium-deprived-rats have abnormal iron metabolism losing homeostatic regulation of plasma iron,
and magnesium deficient rats with dietary iron overload may be used as an experimental hemochromatosis model. |
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Keywords: | Magnesium deficiency iron accumulation iron overload rats mineral imbalance phosphorus calcium |
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